Maybe you can use it more than once, but it seems crazy to do so. After all, the big perk to completing a Lifetime Wish is the lifetime reward points, so if you change it too many times you've thrown that out the window.
Keep in mind that once you've completed a Lifetime Wish, you can't select the reward to have it changed. It's over then.
I think you can only use it once as a 'mid life crisis' thing. If you complete the original lifetime wish then you cannot change to another lifetime wish.
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Keep in mind that once you've completed a Lifetime Wish, you can't select the reward to have it changed. It's over then.