This is a new problem. I had the UC installed since mid-2018 and this has only become a problem within the last week. I've been playing solely in Veronaville for a few months, so I haven't tested other worlds yet. I haven't tried repairing through Origin yet only because I'm scared I'll lose all my progress :/
I have the Ultimate Collection. My game will run for about 5-10 minutes and then crash. It doesn't crash after I do anything specific; it's pretty random.