When I was reviewing the game I created a new save game with a new family (actually downloaded from Gallery because it was created at gamescom) and at first everything seemed fine. Until crashes started to happen
The first few simdays nothing special happend until I was trying to make friends at the goth's house. After clicking an interaction the game crashed, I restarted the game (no auto save happend) tried another social interaction a few simdays later on a sim walking by, again a crash to the desktop. I was thinking this was due to my sim being energized and doing interactions. But for the sake of testing I tried doing no social interactions with other sims than the wife.
But about five simdays since the time I started again, the game crashed again, this time I wasn't interacting with anything. I restarted the game again, now after 3 simdays the game crashed again, without interacting.
So as a developer I started to look for a pattern and I soon found one.
All the crashes happened during day time, there were no noticable glitches or bugs before the crash and the crash happened at random times.
The (possible) Cause
I then came up with what was possible the cause of the crash, Sims spawning for walking by in the neighborhood. They possible crashed the game because they had bad clothing or something.
The (possible) Solution
I decided to use manage households to remove all households that said they weren't in the world (since sims in the world will probably have no bad clothing). I did this and I've now played for 12 simdays straight without a crash. If I get a crash I will update this post.
PC Information and Game information
Since the cause is probably not related to hardware I have minimum specifications here, if the devs want a full DxDiag I can supply that with the save file that crashed (I backed it up before removing the townies).
OS: Windows 7 SP1 Professional 64Bit
CPU: Intel core i7-4790K at 4.0Ghz
GPU: Nvidia GTX 770 2GB
Resolution: Fullscreen at 1920x1080 with 60Ghz monitor
Game settings: Ultra, with uncompressed textures on
Game type: Collector's Edition, with all the Sims 3 reward DLC.
Mods installed: Yes, but only one that removes the highlight (edit's a DATA file, which shouldn't be the cause)